The site mentioned in a previous reply post, called destinationrx.com or
www.drx.com can help with three of the key layers of consideration when trying to manage prescription costs.
The first consideration is what you buy - or therapeutic choices. You can enter medications and see what therapeutic alternatives might save you money based on clinical equivalency. This works for a HDHP user or for a traditionally insured if you enter your plan and benefit design details. You can save as much as 50% through this choice layer alone.
The second consideration is how you buy. This has to do with choosing retail or mail order pharmacies and buying larger quantities in order to get better per-dose pricing. The DestinationRx site will help you to see the differences in costs immediately. You have to change quantities to get a view for pricing. Some of the retailers and mail order houses that are known for better pricing, like Costo or RxUSA.com have the best pricing if you buy 100 pills as opposed to 90 because that is the quantity they buy from the wholesaler so they do not have to repackage. Don't forget you will need a new prescription from your doctor to buy larger quantities.
The third consideration is where you buy. The Destinationrx site allows you to compare pricing at different local and mail order pharmacies. They do not have all of the $4 or free antibiotics programs listed yet, but have been adding them. Some of the pricing is very aggressive. Don't forget to explore different quantities to see if you can get a better deal.
Good luck.